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Suramin Sodium Salt
Price range: 62 CAD through 1,211 CAD
Products Details
Product Description
– Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.
Web ID
– T2160
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C51H34N6Na6O23S6
Citations
– 1. Wan Y, Feng B, You Y, et al. Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures. Cell Reports. 2020, 33(5): 108346
References
– Jindal HK, et al. Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases. Cancer Res. 1990 Dec 15;50(24):7754-7.
CAS Number
– 129-46-4
Molecular Weight
– C51H34N6Na6O23S6
Compound Purity
– 0.9976
SMILES
– [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Cc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(c3cc(cc(c23)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c1)C(=O)Nc1ccc(c2cc(cc(c12)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O
Target
– ADC Linker
Pathway
– Apoptosis|||DNA Damage/DNA Repair|||Chromatin/Epigenetic|||Metabolism|||Microbiology/Virology
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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