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Dynasore

SKU T1848-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 72 CAD through 1,486 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– Dynasore (Dynamin Inhibitor I), a cell-permeable chemical, can reversibly and non-competitivity inhibit GTPase activity of dynamin 1/2 (IC50: 15 μM in a cell-free assay). It also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1848

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H14N2O4

Citations

– 1. Zhao Z, Wei Z, Zheng J, et al.Hepatitis B virus promotes its own replication by enhancing RAB5A-mediated dual activation of endosomal and autophagic vesicle pathways: RAB5A promotes HBV replication.Emerging Microbes & Infections.2023 (just-accepted): 2261556. 2. Zhu X, Zhao Y, Liu Y, et al.Macrophages release IL11-containing filopodial tip vesicles and contribute to renal interstitial inflammation.Cell Communication and Signaling.2023, 21(1): 1-17. 3. Wang T, Wang L, Li W, et al.Fowl adenovirus serotype 4 enters leghorn male hepatocellular cells via the clathrin-mediated endocytosis pathway.Veterinary Research.2023, 54(1): 1-14. 4. Xu L L, Zhang X, Jiang Z Y, et al. Molecular similarity guided optimization of novel Nrf2 activators with 1, 2, 4-oxadiazole core. Bioorganic & medicinal chemistry. 2016, 24(16): 3540-3547. 5. Jiang K, Hou X, Tan T, et al. Scavenger receptor-C acts as a receptor for Bacillus thuringiensis vegetative insecticidal protein Vip3Aa and mediates the internalization of Vip3Aa via endocytosis. PLoS Pathogens. 2018 Oct 4;14(10):e1007347 6. Zhang Y, Xue W, Zhang W, et al. Histone methyltransferase G9a protects against acute liver injury through GSTP1. Cell Death & Differentiation. 2020, 27(4): 1243-1258 7. Zhong B, Shi D, Wu F, et al. Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma. Cell Death & Disease. 2019, 10(10): 1-16 8. Lu J Y, Huang W T, Zhou K, et al. Microbial Lipopeptide Supramolecular Self‐Assemblies as a Methuosis‐Like Cell Death Inducer with In Vivo Antitumor Activity. Small. 2021: 2104034. 9. Wang X, Chen Q Z, Zan Y X, et al. Exosomal miR‐145‐5p derived from orthohantavirus‐infected endothelial cells inhibits HTNV infection. The FASEB Journal. 2020, 34(10): 13809-13825. 10. Xia T, Liu Z, Du Y, et al.Bifunctional iRGD-Exo-DOX crosses the blood-brain barrier to target central nervous system lymphoma.Biochemical Pharmacology.2024: 116138.

References

– Macia E, et al. Dev Cell, 2006, 10(6), 839-850.

CAS Number

– 304448-55-3

Molecular Weight

– C18H14N2O4

Compound Purity

– 0.9989

SMILES

– Oc1ccc(C=NNC(=O)c2cc3ccccc3cc2O)cc1O

Target

– Others

Pathway

– Autophagy|||Microbiology/Virology|||Cytoskeletal Signaling

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.