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Buparlisib

SKU T1827-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 91 CAD through 715 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1827

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H21F3N6O2

Citations

– 1. Wencao Zhao, Le Cao, Hanru Ying, Wenjuan Zhang, Dantong Li, Xiaolong Zhu, Wenzhi Xue, Shuang Wu, Mengye Cao, Cong Fu, Haonan Qi, Yimei Hao, Yun-Chi Tang, Jun Qin, Tao P. Zhong, Xiaoxi Lin, Luyang Yu, Xuri Li, Lin Li, Dianqing Wu & Weijun Pan Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell Research. 2019 2. Hu P, Li H, Yu X, et al. GL-V9 exerts anti-T cell malignancies effects via promoting lysosome-dependent AKT1 degradation and activating AKT1/FOXO3A/BIM axis. Free Radical Biology and Medicine. 2019

References

– Burger MT, et al. Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer. ACS Med Chem Lett. 2011 Aug 26;2(10):774-9.

CAS Number

– 944396-07-0

Molecular Weight

– C18H21F3N6O2

Compound Purity

– 0.9845

SMILES

– Nc1cc(c(cn1)-c1cc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F

Target

– Others

Pathway

– PI3K/Akt/mTOR signaling|||Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.