CMPD101
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CMPD101

SKU T14989-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 96 CAD through 1,003 CAD

Products Details

Product Description

– CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with IC50s of 3.1 μM , 2.3 μM, 1.4 μM and 8.1 μM, respectively.

Web ID

– T14989

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C24H21F3N6O

References

– Okawa T, et al. Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure. J Med Chem. 2017 Aug 24;60(16):6942-6990.

CAS Number

– 865608-11-3

Molecular Weight

– C24H21F3N6O

Compound Purity

– 0.9904

SMILES

– Cn1c(CNc2cccc(c2)C(=O)NCc2ccccc2C(F)(F)F)nnc1-c1ccncc1

Target

– Others

Pathway

– GPCR/G Protein|||Chromatin/Epigenetic|||Cell Cycle/Checkpoint|||Cytoskeletal Signaling|||Stem Cells

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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