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Canagliflozin

SKU T1782-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 69 CAD through 501 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 5 mg 50 mg 500 mg

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Products Details

Product Description

– Canagliflozin (JNJ 28431754AAA) is a selective SGLT2 inhibitor that inhibits CHO cells expressing mSGLT2, rSGLT2, and hSGLT2 (IC50=2/3.7/4.4 nM). Canagliflozin can be used for the [research relevance to related conditions] mellitus (T2DM).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1782

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C24H25FO5S

Citations

– 1. Ding L, Chen X, Zhang W, et al.Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling.The Journal of Clinical Investigation.2023, 133(1). 2. Huang H, Kung F L, Huang Y W, et al.Sensitization of cancer cells to paclitaxel-induced apoptosis by canagliflozin.Biochemical Pharmacology.2024: 116140.

References

– Liang Y, et al. PLoS One. 2012, 7(2), e30555.

CAS Number

– 842133-18-0

Molecular Weight

– C24H25FO5S

Compound Purity

– 0.9801

SMILES

– O[C@H]1[C@@H](O[C@H](CO)[C@@H](O)[C@@H]1O)C2=CC(CC=3SC(=CC3)C4=CC=C(F)C=C4)=C(C)C=C2

Target

– NADPH|||Ferroptosis|||NADPH-oxidase

Pathway

– GPCR/G Protein

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.