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Y-27632 dihydrochloride
Price range: 59 CAD through 691 CAD
Products Details
Product Description
– Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
Web ID
– T1725
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C14H21N3O·2HCl
Citations
– 1. Fu G B, Huang W J, Zeng M, et al. Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens. Cell Research. 2019, 29(1): 8-222. Zhu Y, Wang L, Yu H, et al. In situ generation of human brain organoids on a micropillar array. Lab on A Chip. 2017 Aug 22;17(17):2941-29503. Wen L, Miao Y, Fan Z, et al. Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632. Frontiers in Cell and Developmental Biology. 2021 Mar 5;9:632882. doi: 10.3389/fcell.2021.632882. eCollection 2021.4. Li Z, Luo W, Fang S, et al. Prostacyclin facilitates vascular smooth muscle cell phenotypic transformation via activating TP receptors when IP receptors are deficient. Acta Physiologica. 2020: e135555. Chen X, Lin J, Hu T, et al. Galectin‐3 exacerbates ox‐LDL‐mediated endothelial injury by inducing inflammation via integrin β1‐RhoA‐JNK signaling activation. Journal of Cellular Physiology. 2019 Jul;234(7):10990-110006. Schenke M, Schjeide B M, Püschel G P, et al. Analysis of Motor Neurons Differentiated from Human Induced Pluripotent Stem Cells for the Use in Cell-Based Botulinum Neurotoxin Activity Assays. Toxins. 2020, 12(5): 2767. Zhu Y, Wang L, Yin F, et al. A hollow fiber system for simple generation of human brain organoids. Integrative Biology. 2017 Sep 18;9(9):774-7818. Wang C, Li Y, Jia L, et al. CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance. Cell Stem Cell. 2021 Sep 2;28(9):1597-1613.e7. doi: 10.1016/j.stem.2021.04.011. Epub 2021 May 3.9. Xu L, Kan S, Yu X, et al.Deep learning enables stochastic optical reconstruction microscopy-like superresolution image reconstruction from conventional microscopy.iScience.2023, 26(11).10. Mergani A E, Meurer M, Wiebe E, et al.Alteration of cholesterol content and oxygen level in intestinal organoids after infection with Staphylococcus aureus.The FASEB Journal.2023, 37(12): e23279.
References
– Wu Y, et al. ROCK inhibitor Y27632 promotes proliferation and diminishes apoptosis of marmoset induced pluripotent stem cells by suppressing expression and activity of caspase 3. Theriogenology. 2016 Jan 15;85(2):302-14.
CAS Number
– 129830-38-2
Molecular Weight
– C14H21N3O·2HCl
Compound Purity
– 0.9967
SMILES
– Cl.Cl.C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
Target
– Endogenous Metabolite
Pathway
– Stem Cells|||Apoptosis|||Cell Cycle/Checkpoint|||Cytoskeletal Signaling
Product type
– Small Compound
New Class
– Top-SmallMol
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
