Download Files:

Bufalin

SKU T1719-1 mL * 10 mM (in DMSO) Category Natural Product Brand: TargetMol

Price range: 88 CAD through 315 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 25 mg 5 mg 50 mg

Clear

Products Details

Product Description

– Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in Y cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1719

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C24H34O4

Citations

– 1. Chen F, Zhu L, Hu J, et al. Bufalin attenuates triple‑negative breast cancer cell stemness by inhibiting the expression of SOX2/OCT4. Oncology letters. 2020, 20(5): 1-1. 2. Norcantharidin overcomes vemurafenib resistance in melanoma by inhibiting pentose phosphate pathway and lipogenesis via downregulating the mTOR pathway

References

– Chen YY, et al. Environ Toxicol. 2015 Jan;30(1):74-82.

CAS Number

– 465-21-4

Molecular Weight

– C24H34O4

Compound Purity

– 0.9908

SMILES

– [H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@H](CC[C@]34O)c3ccc(=O)oc3)[C@@]1(C)CC[C@H](O)C2

Target

– Tyrosinase|||NF-κB

Pathway

– Membrane transporter/Ion channel

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.