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GDC-0310
$500 – $4,200
Products Details
Product Description
– GDC-0310 is a selective acyl-sulfonamide Nav1.7 inhibitor, with an IC50 of 0.6 nM for hNav1.7[1].
Web ID
– HY-139081
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C25H29Cl2FN2O4S
References
– [1]Brian S Safina, et al. Discovery of Acyl-sulfonamide Na v 1.7 Inhibitors GDC-0276 and GDC-0310. J Med Chem. 2021 Mar 25;64(6):2953-2966.|[2]Lei Xu, et al. Voltage-gated sodium channels: structures, functions, and molecular modeling. Drug Discov Today. 2019 Jul;24(7):1389-1397.
CAS Number
– 1788063-52-4
Molecular Weight
– 543.48
Compound Purity
– 99.80
SMILES
– O=C(NS(=O)(C)=O)C1=CC(C2CC2)=C(OCC3CCN([C@H](C4=CC(Cl)=CC(Cl)=C4)C)CC3)C=C1F
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 4 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Sodium Channel
Isoform
– Nav1.1;Nav1.2;Nav1.4;Nav1.5;Nav1.6;Nav1.7
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
