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Pevonedistat hydrochloride

SKU T16117-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 77 CAD through 248 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 5 mg

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Products Details

Product Description

– Pevonedistat hydrochloride (MLN4924 hydrochloride) is a selective and potent NEDD8 activating enzyme inhibitor (IC50: 4.7 nM) that induces apoptosis and cell cycle inhibition in cancer cells, and is used in the study of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Pelubiprofen has been used in the study of AML and MDS.)

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T16117

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H26ClN5O4S

References

– Soucy TA, et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature. 2009 Apr 9;458(7239):732-6.

CAS Number

– 1160295-21-5

Molecular Weight

– C21H26ClN5O4S

Compound Purity

– 0.9919

SMILES

– N(C1=C2C(N(C=C2)[C@@H]3C[C@@H](COS(N)(=O)=O)[C@@H](O)C3)=NC=N1)[C@@H]4C=5C(CC4)=CC=CC5.Cl

Target

– Apoptosis

Pathway

– Metabolism|||Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.