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Lenalidomide-OH
$180 – $540
Products Details
Product Description
– Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 (HY-133137)[1].
Web ID
– HY-133144
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C13H12N2O4
References
– [1]Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.
CAS Number
– 1416990-08-3
Molecular Weight
– 260.25
Compound Purity
– 99.48
SMILES
– O=C(C(N(CC1=C2C=CC(O)=C1)C2=O)CC3)NC3=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 13.89 mg/mL (ultrasonic)
Target
– Ligands for E3 Ligase
Isoform
– Cereblon
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
