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Rapamycin
Price range: 48 CAD through 475 CAD
Products Details
Product Description
– Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
Web ID
– T1537
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C51H79NO13
Citations
– 1. Yan C, Zheng L, Jiang S, et al.Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity.Cancer Cell.2023
2. Cai Z, Wu X, Song Z, et al.Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis.Cell Discovery.2023, 9(1): 104.
3. Yu Q, Li C, Niu Q, et al.Hepatic COX1 loss leads to impaired autophagic flux and exacerbates nonalcoholic steatohepatitis.Acta Pharmaceutica Sinica B.2023
4. Zhuang J, Shen L, Li M, et al.Cancer-associated fibroblast-derived miR-146a-5p generates a niche that promotes bladder cancer stemness and chemoresistance.Cancer Research.2023: CAN-22-2213.
5. Ma W, Wu Q, Wang S, et al.A breakdown of metabolic reprogramming in microglia induced by CKLF1 exacerbates immune tolerance in ischemic stroke.Journal of Neuroinflammation.2023, 20(1): 1-23.
6. Cao Y, Chen X, Pan F, et al.Xinmaikang-mediated Mitophagy Attenuates Atherosclerosis via the PINK1/Parkin Signaling Pathway.Phytomedicine.2023: 154955.
7. Long T, Chen X, Zhang Y, et al.Protective effects of Radix Stellariae extract against Alzheimer’s disease via autophagy activation in Caenorhabditis elegans and cellular models.Biomedicine & Pharmacotherapy.2023, 165: 115261.
8. Liu X, Xi H, Han S, et al.Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.Ecotoxicology and Environmental Safety.2023, 252: 114571.
9. Han S, Zhang H, Liu X, et al.Enhanced autophagy reversed aflatoxin B1-induced decrease in lactate secretion of dairy goat Sertoli cells.Ecotoxicology and Environmental Safety.2023, 259: 115063.
10. Li W Y, Shi T S, Huang J, et al.Activation of the mTORC1 signaling cascade in the hippocampus and medial prefrontal cortex is required for the antidepressant actions of vortioxetine in mice.International Journal of Neuropsychopharmacology.2023: pyad017.
References
– Pallet N, et al. Rapamycin inhibits human renal epithelial cell proliferation: effect on cyclin D3 mRNA expression and stability. Kidney Int. 2005 Jun;67(6):2422-33.
CAS Number
– 53123-88-9
Molecular Weight
– C51H79NO13
Compound Purity
– 0.998
SMILES
– [H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N1CCCC[C@@]1([H])C(=O)O[C@@]([H])(CC(=O)[C@H](C)C=C(C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)C=CC=CC=C(C)[C@H](C2)OC)[C@H](C)C[C@@H]1CC[C@@H](O)[C@@H](C1)OC
Target
– Others
Pathway
– PI3K/Akt/mTOR signaling|||Metabolism|||Autophagy|||Microbiology/Virology
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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