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Products Details
Product Description
– AMPK activator 2 (compound 7a), a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549)[1].
Web ID
– HY-130723
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C13H18F3N5
References
– [1]Di Xiao, et al. Synthesis, biological evaluation and anti-proliferative mechanism of fluorine-containing proguanil derivatives. Bioorg Med Chem. 2020 Jan 15;28(2):115258.
CAS Number
– 2410961-69-0
Molecular Weight
– 301.31
SMILES
– N=C(NC(NC1=CC=C(C(F)(F)F)C=C1)=N)NCC(C)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– AMPK
Isoform
– AMPK
Pathway
– Epigenetics;PI3K/Akt/mTOR
Product type
– Reference compound
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