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MK 0893

SKU T12055-25 mg Category Small Compound Brand: TargetMol

Price range: 2,992 CAD through 7,920 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– MK 0893 is a potent and selective Glucagon Receptor (GR) antagonist (IC50=6.6 nM) with competitive, reversible, high binding affinity and functional cAMP activity, which attenuates glucagon induced blood glucose elevation and reduces ambient glucose levels in acute and chronic mouse models.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T12055

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C32H27Cl2N3O4

References

– Xiong Y, et al. Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the treatment of type II diabetes.J Med Chem. 2012 Jul 12;

CAS Number

– 870823-12-4

Molecular Weight

– C32H27Cl2N3O4

SMILES

– [C@@H](C)(N1C(=CC(=N1)C2=CC(Cl)=CC(Cl)=C2)C3=CC4=C(C=C3)C=C(OC)C=C4)C5=CC=C(C(NCCC(O)=O)=O)C=C5

Target

– Others

Pathway

– GPCR/G Protein

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.