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Temozolomide
Price range: 67 CAD through 398 CAD
Products Details
Product Description
– Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy. Temozolomide is stable under acidic conditions and hydrolyzes under neutral or slightly alkaline conditions.
Web ID
– T1178
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C6H6N6O2
Citations
– 1. Wang Y, Wang X, Wang K, et al.Chronic stress accelerates glioblastoma progression via DRD2/ERK/β-catenin axis and Dopamine/ERK/TH positive feedback loop.Journal of Experimental & Clinical Cancer Research.2023, 42(1): 1-17.
2. Liu X, Guo C, Leng T, et al.Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell.Cell Death & Disease.2023, 14(2): 142.
3. Liu X, Guo Q, Gao G, et al.Exosome-transmitted circCABIN1 promotes temozolomide resistance in glioblastoma via sustaining ErbB downstream signaling.Journal of Nanobiotechnology.2023, 21(1): 1-25.
4. Chen Y, Guo Y, Li S, et al.Remdesivir inhibits the progression of glioblastoma by enhancing endoplasmic reticulum stress.Biomedicine & Pharmacotherapy.2023, 157: 114037.
5. Dong J, Peng Y, Zhong M, et al.Implication of lncRNA ZBED3-AS1 downregulation in acquired resistance to Temozolomide and glycolysis in glioblastoma.European Journal of Pharmacology.2022: 175444.
6. Tong S, Hong Y, Xu Y, et al.TFR2 regulates ferroptosis and enhances temozolomide chemo-sensitization in gliomas.Experimental Cell Research.2023: 113474.
7. Jiao W, Zhu S, Shao J, et al. ZSTK474 Sensitizes Glioblastoma to Temozolomide by Blocking Homologous Recombination Repair. BioMed Research International. 2022
8. Li J, Sun Y, Sun X, et al. AEG-1 silencing attenuates M2-polarization of glioma-associated microglia/macrophages and sensitizes glioma cells to temozolomide. Scientific reports. 2021, 11(1): 1-12.
9. Wang Y, Wang X, Wang X, et al. Imipramine impedes glioma progression by inhibiting YAP as a Hippo pathway independent manner and synergizes with temozolomide. Journal of Cellular and Molecular Medicine. 2021
10. Zhang B, Xu C, Liu J, et al. Nidogen-1 expression is associated with overall survival and temozolomide sensitivity in low-grade glioma patients. Aging (Albany NY). 2021 Mar 18;13(6):9085-9107. doi: 10.18632/aging.202789. Epub 2021 Mar 18.
References
– Mhaidat NM, et al. Temozolomide induces senescence but not apoptosis in human melanoma cells. Br J Cancer. 2007 Nov 5;97(9):1225-33.
CAS Number
– 85622-93-1
Molecular Weight
– C6H6N6O2
Compound Purity
– 0.9897
SMILES
– CN1N=NC2=C(N=CN2C1=O)C(N)=O
Target
– Others
Pathway
– Autophagy|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Apoptosis
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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