EGFR-IN-11
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EGFR-IN-11

SKU T11158-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 75 CAD through 942 CAD

Products Details

Product Description

– EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1.

Web ID

– T11158

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C29H35N9O2S

References

– Lei H, et al. Discovery of novel 9-heterocyclyl substituted 9H-purines as L858R/T790M/C797S mutant EGFR tyrosine kinase inhibitors. Eur J Med Chem. 2019 Nov 16:111888.

CAS Number

– 2463200-44-2

Molecular Weight

– C29H35N9O2S

Compound Purity

– 0.9937

SMILES

– CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n([C@@H]4CCN(C4)S(=O)(=O)C4CC4)c3n2)cc1

Target

– GPCR

Pathway

– Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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