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Roflumilast

SKU T1024-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 80 CAD through 422 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 5 mg 50 mg

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Products Details

Product Description

– Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activities. Upon administration, roflumilast and its active metabolite roflumilast N-oxide selectively and competitively bind to and inhibit PDE4, which leads to an increase of both intracellular levels of cyclic-3′, 5′-adenosine monophosphate (cAMP) and cAMP-mediated signaling.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1024

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C17H14Cl2F2N2O3

Citations

– 1. Chen L, Ye T, Wang X, et al.Decoction on Major Depressive Disorder based on Network Pharmacology and Molecular Docking.Combinatorial Chemistry & High Throughput Screening.2023, 26(9): 1701-1728. 2. Wang B, Zhu X, Yu S, et al.Roflumilast ameliorates GAN diet-induced non-alcoholic fatty liver disease by reducing hepatic steatosis and fibrosis in ob/ob mice.Biochemical and Biophysical Research Communications.2024: 150170.

References

– Hatzelmann A, et al. Pulm Pharmacol Ther, 2010, 23(4), 235-256.

CAS Number

– 162401-32-3

Molecular Weight

– C17H14Cl2F2N2O3

Compound Purity

– 0.9976

SMILES

– O(CC1CC1)C2=C(OC(F)F)C=CC(C(NC=3C(Cl)=CN=CC3Cl)=O)=C2

Target

– Others

Pathway

– Metabolism|||Microbiology/Virology

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.