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5-Iodo-indirubin-3′-monoxime

SKU T10172-5 mg Category Small Compound Brand: TargetMol

Price range: 475 CAD through 2,976 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– 5-Iodo-indirubin-3′-monoxime is a potent inhibitor of GSK-3β, CDK5/P25, and CDK1/cyclin B, competing with ATP for binding to the catalytic site of the kinase (IC50s: 9, 20, and 25 nM).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T10172

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C16H10IN3O2

References

– Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60.

CAS Number

– 331467-03-9

Molecular Weight

– C16H10IN3O2

SMILES

– ON=C1C(Nc2ccccc12)=C1C(=O)Nc2ccc(I)cc12

Target

– Others

Pathway

– Cell Cycle/Checkpoint|||PI3K/Akt/mTOR signaling|||Stem Cells

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.