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Cyclosporin A

SKU T0945-1 mL * 10 mM (in DMSO) Category Natural Product Brand: TargetMol

Price range: 58 CAD through 106 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)100 mg 200 mg 50 mg

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Products Details

Product Description

– Cyclosporin A is a naturally occurring cyclic polypeptide that is the active metabolite of a fungus. Cyclosporin A is an immunosuppressant that binds to procyclins and inhibits calcineurin (IC50=7 nM).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T0945

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C62H111N11O12

Citations

– 1. Bao, Shixiang, et al. TGF-β1 Induces Immune Escape by Enhancing PD-1 and CTLA-4 Expression on T Lymphocytes in Hepatocellular Carcinoma. Frontiers in Oncology. 11 (2021): 2516. 2. Song J, Zou D, Zhao X, et al. Bufalin inhibits human diffuse large B-cell lymphoma tumorigenesis by inducing cell death through the Ca2+/NFATC1/cMYC pathway. Carcinogenesis. 2020 3. Liu J, Giri B R, Chen Y, et al. Schistosoma japonicum IAP and Teg20 safeguard tegumental integrity by inhibiting cellular apoptosis. PLoS Neglected Tropical Diseases. 2018 Jul 25;12(7):e0006654 4. Ren Y, Tong X, Zhao Y, et al. Dolabrane-Type Diterpenoids with Immunosuppressive Activity from Koilodepas hainanense. Journal of Natural Products. 2022 5. Zheng B X, Long W, Zheng W, et al.Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy.Journal of Medicinal Chemistry.2024 6. He Y, Xu D, Zhang J, et al.Bergenin, the main active ingredient of Bergenia purpurascens, attenuates Th17 cell differentiation by downregulating fatty acid synthesis.The FASEB Journal.2024, 38(19): e70095. 7. Wu Y, Tang K, Wang C, et al.Establishment of interpretable cytotoxicity prediction models using machine learning analysis of transcriptome features.Acta Pharmaceutica Sinica B.2025

References

– D’Angelo G, et al. Cyclosporin A prevents the hypoxic adaptation by activating hypoxia-inducible factor-1alpha Pro-564 hydroxylation. J Biol Chem. 2003 Apr 25;278(17):15406-11.

CAS Number

– 59865-13-3

Molecular Weight

– C62H111N11O12

Compound Purity

– 0.9999

SMILES

– [C@H]([C@@H](C/C=C/C)C)(O)[C@@]1(N(C)C(=O)[C@H]([C@@H](C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H]([C@H](C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC1=O)[H]

Target

– Others

Pathway

– Metabolism|||Immunology/Inflammation|||Microbiology/Virology

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.