![](https://immunomart.com/wp-content/uploads/2024/03/HY-151559.gif)
Download Files:
Zn-DPA-maytansinoid conjugate 1
SKU
HY-151559-Get quote
Category Reference compound
Tags Cancer, CCR;Checkpoint Kinase (Chk);CXCR;STAT, Cell Cycle/DNA Damage;GPCR/G Protein;Immunology/Inflammation;JAK/STAT Signaling;Stem Cell/Wnt
Products Details
Product Description
– Zn-DPA-maytansinoid conjugate 1 is a small molecule-based maytansinoid conjugate targeting immune checkpoint. Zn-DPA-maytansinoid conjugate 1 induces lasting regression of tumor growth and rejuvenates tumor microenvironment (TME) to an “inflamed hot tumor”[1].
Web ID
– HY-151559
Shipping
– Room temperature
Molecular Formula
– C115H145ClN18O31S2Zn2
References
– [1]Lo CF, et al. Targeting the Phosphatidylserine-Immune Checkpoint with a Small-Molecule Maytansinoid Conjugate. J Med Chem. 2022 Oct 13;65(19):12802-12824.
Molecular Weight
– 2505.83
SMILES
– [O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.C[C@@H](N(C)C(CCSSCCC(NCC1=CC=C(C=C1)CNC(COCCOCCOCC(N(CC2=CC=C(C3=CC=CC=C3)C=C2)CCCCOC4=CC(C[N]5(CC6=CC=CC=[N]6[Zn+2]75)CC8=[N]7C(NC(CCCCC)=O)=CC=C8)=CC(C[N]9(CC%10=CC=CC=[N]%10[Zn+2]%119)CC%12=[N]%11C(NC(CCCCC)=O)=CC=C%12)=C4)=O)=O)=O)=O)C(O[C@H]([C@](C%13[C@H]([C@H](OC(N%14)=O)C[C@@]%14(O)[C@@H](OC)/C=CC=C(C)CC%15=CC(OC)=C(Cl)C%16=C%15)C)(O%13)C)CC(N%16C)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– CCR;Checkpoint Kinase (Chk);CXCR;STAT
Pathway
– Cell Cycle/DNA Damage;GPCR/G Protein;Immunology/Inflammation;JAK/STAT Signaling;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.