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Products Details
Product Description
– Zn-DPA-maytansinoid conjugate 1 is a small molecule-based maytansinoid conjugate targeting immune checkpoint. Zn-DPA-maytansinoid conjugate 1 induces lasting regression of tumor growth and rejuvenates tumor microenvironment (TME) to an “inflamed hot tumor”[1].
Web ID
– HY-151559
Shipping
– Room temperature
Molecular Formula
– C115H145ClN18O31S2Zn2
References
– [1]Lo CF, et al. Targeting the Phosphatidylserine-Immune Checkpoint with a Small-Molecule Maytansinoid Conjugate. J Med Chem. 2022 Oct 13;65(19):12802-12824.
Molecular Weight
– 2505.83
SMILES
– [O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.C[C@@H](N(C)C(CCSSCCC(NCC1=CC=C(C=C1)CNC(COCCOCCOCC(N(CC2=CC=C(C3=CC=CC=C3)C=C2)CCCCOC4=CC(C[N]5(CC6=CC=CC=[N]6[Zn+2]75)CC8=[N]7C(NC(CCCCC)=O)=CC=C8)=CC(C[N]9(CC%10=CC=CC=[N]%10[Zn+2]%119)CC%12=[N]%11C(NC(CCCCC)=O)=CC=C%12)=C4)=O)=O)=O)=O)C(O[C@H]([C@](C%13[C@H]([C@H](OC(N%14)=O)C[C@@]%14(O)[C@@H](OC)/C=CC=C(C)CC%15=CC(OC)=C(Cl)C%16=C%15)C)(O%13)C)CC(N%16C)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– CCR;Checkpoint Kinase (Chk);CXCR;STAT
Pathway
– Cell Cycle/DNA Damage;GPCR/G Protein;Immunology/Inflammation;JAK/STAT Signaling;Stem Cell/Wnt
Product type
– Reference compound
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