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Xaliproden (hydrochloride)
$120 – $890
Products Details
Product Description
– Xaliproden hydrochloride (SR57746A) is a potent, selective and orally active agonist of 5-HT1A receptor, shows a high affinity for 5-HT1A specific binding sites in the rat hippocampus (IC50=3 nM). Xaliproden hydrochloride is also a selective antagonist of dopamine D2 receptor, has moderate affinity (IC50=0.1-1 μM). Xaliproden hydrochloride exhibits anti-depression and anti-anxiety effects, and it may possess therapeutic potential for the research of neurodegenerative diseases[1][2][3].
Web ID
– HY-14604
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C24H23ClF3N
References
– [1]Cervo L, et, al. Potential antidepressant properties of SR 57746A, a novel compound with selectivity and high affinity for 5-HT1A receptors. Eur J Pharmacol. 1994 Feb 21; 253(1-2): 139-47.|[2]Simiand J, et, al. Neuropsychopharmacological profile in rodents of SR 57746A, a new, potent 5-HT1A receptor agonist. Fundam Clin Pharmacol. 1993;7(8):413-27.|[3]Fournier J, et, al. Protective effects of SR 57746A in central and peripheral models of neurodegenerative disorders in rodents and primates. Neuroscience. 1993 Aug; 55(3): 629-41.
CAS Number
– 90494-79-4
Molecular Weight
– 417.89
Compound Purity
– 99.05
SMILES
– FC(C1=CC(C2=CCN(CCC3=CC=C4C=CC=CC4=C3)CC2)=CC=C1)(F)F.[H]Cl
Clinical Information
– Phase 3
Research Area
– Neurological Disease
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)
Target
– 5-HT Receptor;Dopamine Receptor
Isoform
– 5-HT1 Receptor;D2 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
