Vandetanib
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Vandetanib

SKU T1656-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 72 CAD through 637 CAD

Products Details

Product Description

– Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 (IC50: 40 nM). It also inhibits VEGFR3 and EGFR.

Web ID

– T1656

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C22H24BrFN4O2

Citations

– 1. Jin Y, Chen X, Gao Z, et al. Bisdemethoxycurcumin alleviates vandetanib-induced cutaneous toxicity in vivo and in vitro through autophagy activation. Biomedicine & Pharmacotherapy. 2021, 144: 112297. 2. Chang Z, Zhang Y, Liu J, et al. Snail promotes the generation of vascular endothelium by breast cancer cells. Cell Death & Disease. 2020, 11(6): 1-17

References

– Wedge SR, et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res. 2002 Aug 15;62(16):4645-55.

CAS Number

– 443913-73-3

Molecular Weight

– C22H24BrFN4O2

Compound Purity

– 0.9984

SMILES

– COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1

Pathway

– JAK/STAT signaling|||Autophagy|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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