TX1-85-1

SKU T17182-1 mg Category Small Compound Brand: TargetMol

Price range: 102 CAD through 915 CAD

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Product Description

– TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3.

Web ID

– T17182

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C32H36N8O3

References

– Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10(12):1006-12.

CAS Number

– 1603845-32-4

Molecular Weight

– C32H36N8O3

Compound Purity

– 0.9812

SMILES

– CC(=O)N1CCN(CC1)C1CCC(CC1)n1nc(-c2ccc(Oc3ccccc3)c(NC(=O)C=C)c2)c2c(N)ncnc12

Target

– NF-κB|||Antioxidant

Pathway

– Angiogenesis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

TX1-85-1

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