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Topotecan
$38 – $180
Products Details
Product Description
– Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity[1].
Web ID
– HY-13768
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C23H23N3O5
Citations
– Acta Pharmacol Sin. 2021 Jan;42(1):108-114.|bioRxiv. 2023 Apr 14.|Cancer Immunol Res. 2023 Mar 15;CIR-22-0483.|Cancers (Basel). 2022, 14(1), 193.|J Biomed Inform. 2023 May 15;104383.|J Exp Clin Cancer Res. 2018 Dec 20;37(1):321. |J Immunol. 2022 Jun 20;ji2100963.|Nat Commun. 2019 Aug 21;10(1):3761.|Pharmaceutics. 2022, 14(12), 2595|Phytochemistry. 2021 Sep 1;191:112910.|Sci Rep. 2019 Oct 22;9(1):15099. |Biochem Pharmacol. 2023 Aug 25;115769.|Cancer Res. 2023 Nov 21:OF1-OF15.|FASEB Bioadv. 2020 Mar 7;2(4):254-263.|J Extracell Vesicles. 2022 Apr;11(4):e12206.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|J Virol. 2019 May 15;93(11):e02230-18. |Universitat Autònoma de Barcelona. Biologia Molecular i Biomedicina. 2022 Aug.
References
– [1]Zhang FL, et al. PLoS One. 2013 Nov 26;8(11):e81815.Topoisomerase I inhibitors, Shikonin and Topotecan, inhibit growth and induce apoptosis of glioma cells andglioma stem cells.|[2]Kumar S, et al. Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clin Cancer Res. 2011 Sep 1;17(17):5656-67.
CAS Number
– 123948-87-8
Molecular Weight
– 421.45
SMILES
– O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C)C)C(O)=CC=C5N=C4C3=C2)=O
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Autophagy;Topoisomerase
Isoform
– Topo I
Pathway
– Apoptosis;Autophagy;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
