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Products Details
Product Description
– TOPK-p38/JNK-IN-1 (Compound B12) is an orally active TOPK-p38/JNK signaling pathway inhibitor with the IC50 value of 2.14 µM for NO production. TOPK-p38/JNK-IN-1 shows anti-inflammatory activities. TOPK-p38/JNK-IN-1 also inhibits phosphorylate downstream related proteins and avoids degradation of TOPK[1].
Web ID
– HY-144761
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C17H15F3N2O4
References
– [1]Jing Wu, et al. Discovery of novel paeonol-based derivatives against skin inflammation in vitro and in vivo. Journal of Enzyme Inhibition and Medicinal Chemistry, 37:1, 817-831.
CAS Number
– 2745108-35-2
Molecular Weight
– 368.31
SMILES
– O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC(C(C)=O)=C(O)C=C2OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– JNK
Isoform
– JNK
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
