TMC647055 Choline Hydroxide Salt
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TMC647055 Choline Hydroxide Salt

SKU T21537L-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 163 CAD through 1,808 CAD

Products Details

Product Description

– TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. It has nanomolar cellular potency (EC(50) of 82 nM) with minimal associated cell toxicity (CC(50)>20 μM) and promising pharmacokinetic profiles in rats and dogs. TMC647055 showed promising in vitro biochemical, kinetic, and virological profile that is currently undergoing clinical evaluation.

Web ID

– T21537L

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C37H53N5O8S

References

– Wang H, et al. Molecular modeling study on the drug resistance mechanism of NS5B polymerase to TMC64705Biochem Cell Biol. 2016 Apr;94(2):147-58.

Molecular Weight

– C37H53N5O8S

Compound Purity

– 0.9944

SMILES

– CN(CCOCCN1C)C(C2=CC3=C(C=CC(OC)=C3)C4=C(C5CCCCC5)C(C=CC(/C(O)=N/S1(=O)=O)=C6)=C6N4C2)=O.OCC[N+](C)(C)C.[OH-]

Pathway

– Proteases/Proteasome|||Microbiology/Virology

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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