Tirapazamine
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Tirapazamine

SKU T4434-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 48 CAD through 429 CAD

Products Details

Product Description

– Tirapazamine (Win59075) is a potent cytotoxic agent under hypoxic conditions, can induce apoptosis by inducing breaks in single and double-stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to other ionizing radiation and other cytotoxic agents like cisplatin.

Web ID

– T4434

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C7H6N4O2

Citations

– 1. Liu C, Jia S, Tu L, et al. GSH-Responsive and Hypoxia-Activated Multifunctional Nanoparticles for Synergetically Enhanced Tumor Therapy. ACS Biomaterials Science & Engineering. 2022 2. Wu Z, Wang Y, Li L, et al.New insights into the antimicrobial action and protective therapeutic effect of tirapazamine towards Escherichia coli-infected mice.International Journal of Antimicrobial Agents.2023: 106923.

References

– Cai T Y, Liu X W, Zhu H, et al. Tirapazamine sensitizes hepatocellular carcinoma cells to topoisomerase I inhibitors via cooperative modulation of hypoxia-inducible factor-1α[J]. Molecular cancer therapeutics, 2013: molcanther. 0490.2013.

CAS Number

– 27314-97-2

Molecular Weight

– C7H6N4O2

Compound Purity

– 0.9915

SMILES

– On1c2ccccc2[n+]([O-])nc1=N

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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