THZ531
Add to CompareAdded to Compare

Download Files:

THZ531

SKU T4293-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 91 CAD through 2,384 CAD

Products Details

Product Description

– THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).

Web ID

– T4293

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C30H32ClN7O2

Citations

– 1. Zhang G M, Huang S S, Ye L X, et al. Reciprocal positive regulation between BRD4 and YAP in GNAQ-mutant uveal melanoma cells confers sensitivity to BET inhibitors. Pharmacological Research. 2022: 106464. 2. Qiu M, Yin Z, Wang H, et al.CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation.Science Advances.2023, 9(20): eadf8698.

References

– Zhang T, et al. Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. Nat Chem Biol. 2016 Oct;12(10):876-84.

CAS Number

– 1702809-17-3

Molecular Weight

– C30H32ClN7O2

Compound Purity

– 0.9986

SMILES

– CN(C)CC=CC(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12

Pathway

– Cell Cycle/Checkpoint

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Related Products

Select options
Aspirin
Aspirin Price range: 50 CAD through 139 CAD
1 g1 mL * 10 mM (in DMSO)5 g

1000 in stock

Select options
Phenytoin sodium
Phenytoin sodium Price range: 72 CAD through 85 CAD
1 g1 mL * 10 mM (in DMSO)500 mg

1000 in stock

Select options
Ethamsylate
Ethamsylate 46 CAD
1 mL * 10 mM (in DMSO)50 mg

1000 in stock

Select options
4-Ethoxycoumarin
4-Ethoxycoumarin 46 CAD
1 g1 mL * 10 mM (in DMSO)

1000 in stock

Select options
Jedi2
Jedi2 Price range: 53 CAD through 1,117 CAD
1 mg1 mL * 10 mM (in DMSO)5 mg

1000 in stock

My Cart
Wishlist
Recently Viewed
Categories

Request Data Sheet / Safty Data Sheet

Please enable JavaScript in your browser to complete this form.
=

Price Request

Please enable JavaScript in your browser to complete this form.
=

Compare Products (0 Products)
document.addEventListener('elementor/popup/show', function() { if (typeof turnstile !== 'undefined') { document.querySelectorAll('.cf-turnstile').forEach(function(el) { if (!el.dataset.rendered) { turnstile.render(el); el.dataset.rendered = true; } }); } });