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Thymidine
Price range: 72 CAD through 80 CAD
Products Details
Product Description
– Thymidine (DThyd) is a cell synchronizing agent and a specific precursor of deoxyribonucleic acid. Thymidine inhibits DNA synthesis and can cause cell cycle arrest in the G1/S phase.
Web ID
– TWP2911
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C10H14N2O5
Citations
– 1. Zhao Y, Yang J, Lu D, et al.The Loss-Function of KNL1 Causes Oligospermia and Asthenospermia in Mice by Affecting the Assembly and Separation of the Spindle through Flow Cytometry and Immunofluorescence.Sensors.2023, 23(5): 2571.
2. Wang J, Chen Y, Li S, et al.PP2A inhibition causes synthetic lethality in BRCA2-mutated prostate cancer models via reactivating spindle assembly checkpoint.The Journal of Clinical Investigation.2023
3. Zheng M, Li J, Guo H, et al.IMPDH inhibitors upregulate PD-L1 in cancer cells without impairing immune checkpoint inhibitor efficacy.Acta Pharmacologica Sinica.2024: 1-10.
References
– Sun R , Wang L . Thymidine Kinase 2 Enzyme Kinetics Elucidate the Mechanism of Thymidine-Induced Mitochondrial DNA Depletion[J]. Biochemistry, 2014, 53(39):6142-6150.
CAS Number
– 50-89-5
Molecular Weight
– C10H14N2O5
Compound Purity
– 0.9964
SMILES
– O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(C)C(=O)N1
Pathway
– Metabolism|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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