STM2457
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STM2457

SKU T9060-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 162 CAD through 1,325 CAD

Products Details

Product Description

– STM2457 is an inhibitor of the RNA methyltransferase METTL3 (IC50=16.9 nM) with selective and oral activity.STM2457 can be used in acute myeloid leukemia (AML) studies.

Web ID

– T9060

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C25H28N6O2

Citations

– 1. Xu Q C, Tien Y C, Shi Y H, et al. METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m6A-YTHDF2-dependent manner. Oncogene. 2022: 1-12. 2. Zhao T, Zhao R, Yi X, et al. METTL3 promotes proliferation and myogenic differentiation through m6A RNA methylation/YTHDF1/2 signaling axis in myoblasts. Life Sciences. 2022: 120496. 3. Wang D, Wang D, Jin Q, et al.Suxiao Jiuxin Pill Alleviates Myocardial Ischemia/Reperfusion-Induced Autophagy via miR-193a-3p/ALKBH5 Pathway.Phytomedicine.2024: 155359. 4. Li J, Wei L, Hu K, et al.Deciphering m6A methylation in monocyte-mediated cardiac fibrosis and monocyte-hitchhiked erythrocyte microvesicle biohybrid therapy.Theranostics.2024, 14(9): 3486. 5. Pupak A, Rodríguez-Navarro I, Sathasivam K, et al.m6A modification of mutant huntingtin RNA promotes the biogenesis of pathogenic huntingtin transcripts.EMBO reports.2024: 1-27. 6. Zhou Q, Liu X, Lu H, et al.m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells.Journal of Neuroinflammation.2024, 21(1): 289.

References

– Yankova E, et al. Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature. 2021 May;593(7860):597-601.

CAS Number

– 2499663-01-1

Molecular Weight

– C25H28N6O2

Compound Purity

– 0.9942

SMILES

– O=C(NCc1cn2cc(CNCC3CCCCC3)ccc2n1)c1cc(=O)n2ccccc2n1

Pathway

– Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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