SR-4835
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SR-4835

SKU T8325-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 82 CAD through 2,832 CAD

Products Details

Product Description

– SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (TNBC) cells

Web ID

– T8325

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H20Cl2N10O

Citations

– 1. Dai W, Wu J, Peng X, et al. CDK12 orchestrates super‐enhancer‐associated CCDC137 transcription to direct hepatic metastasis in colorectal cancer. Clinical and Translational Medicine. 2022, 12(10): e1087. 2. Wu Z, Wang M, Li F, et al. CDK13-Mediated Cell Cycle Disorder Promotes Tumorigenesis of High HMGA2 Expression Gastric Cancer. Frontiers in Molecular Biosciences. 2021, 8. 3. Liu S, Wu J, Lu X, et al.Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/β-catenin signaling pathway.Experimental Cell Research.2023: 113613.

References

– Quereda V, et al. Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer. Cancer Cell. 2019 Oct 8. pii: S1535-6108(19)30424-6.

CAS Number

– 2387704-62-1

Molecular Weight

– C21H20Cl2N10O

Compound Purity

– 0.9803

SMILES

– Cn1cc(cn1)-n1cnc2c(NCc3nc4cc(Cl)c(Cl)cc4[nH]3)nc(nc12)N1CCOCC1

Pathway

– Cell Cycle/Checkpoint|||Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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