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Sivelestat (sodium tetrahydrate)
$54 – $420
Products Details
Product Description
– Sivelestat (EI546) sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4].
Web ID
– HY-17443B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H29N2NaO11S
Citations
– Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|Oxid Med Cell Longev. 2019 Nov 23;2019:7323986.|Biofabrication. 2021 Feb 1.|Burns Trauma. 17 September 2021.|Cancers (Basel). 2022, 14(3), 515.|Cell Biosci. 2022 Jul 22;12(1):114.|Ecotoxicol Environ Saf. 2023 Nov 18:268:115694.|J Cell Mol Med. 2022 Feb 11.|J Exp Med. 2023 Sep 4;220(9):e20221751.|J Infect Dis. 2023 Nov 28:jiad526.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|Research Square Preprint. 2021 Aug.|Research Square Preprint. 2021 Jun.|J Hepatocell Carcinoma. 2021 May 20;8:451-465.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.
References
– [1]Kawabata K, et al. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20.|[2]Yuichiro Toda, et al. A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats. Int J Mol Med. 2007 Feb;19(2):237-43.|[3]Tomoharu Kono, et al. Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. Mol Cell Biochem. 2008 Apr;311(1-2):87-92.|[4]Adeleh Sahebnasagh, et al. Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. J Clin Pharm Ther. 2020 Aug 28.
CAS Number
– 201677-61-4
Molecular Weight
– 528.51
Compound Purity
– 99.90
SMILES
– CC(C)(C)C(OC1=CC=C(S(=O)(NC2=CC=CC=C2C(NCC(O[Na])=O)=O)=O)C=C1)=O.O.O.O.O
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Elastase;SARS-CoV
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
