Download Files:
Silmitasertib
Price range: 54 CAD through 1,872 CAD
For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.
Products Details
Product Description
– Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).
Web ID
– T2259
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C19H12ClN3O2
Citations
– 1. Wang C, Tian L, He Q, et al.Targeting CK2-mediated phosphorylation of p53R2 sensitizes BRCA-proficient cancer cells to PARP inhibitors.Oncogene.2023: 1-14.
2. Werner C, Lindenblatt D, Viht K, et al.Discovery and Exploration of Protein Kinase CK2 Binding Sites Using CK2α′ Cys336Ser as an Exquisite Crystallographic Tool.Kinases and Phosphatases.2023, 1(4): 306-322.
3. Haga Y, Ray R, Ray R B.Silmitasertib in Combination With Cabozantinib Impairs Liver Cancer Cell Cycle Progression, Induces Apoptosis, and Delays Tumor Growth in a Preclinical Model.Molecular Carcinogenesis.2024
References
– Siddiqui-Jain A, et al. CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res. 2010 Dec 15;70(24):10288-98.
CAS Number
– 1009820-21-6
Molecular Weight
– C19H12ClN3O2
Compound Purity
– 0.9961
SMILES
– OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21
Pathway
– Metabolism|||Autophagy|||Stem Cells
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
