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Products Details
Product Description
– SEL120-34A is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.
Web ID
– HY-111388
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C15H18Br2N4
Citations
– Friedrich-Alexander-Universität Erlangen-Nürnberg. 2023 Jun 23.|Nat Commun. 2019 Oct 18;10(1):4741. |Cell. 2021 Apr 15;184(8):2167-2182.e22.|Int J Mol Sci. 2022 Feb 24;23(5):2493.
References
– [1]Rzymski T, et al. SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Oncotarget. 2017 May 16;8(20):33779-33795.
CAS Number
– 1609522-33-9
Molecular Weight
– 414.14
SMILES
– CC1=C2C3=C(C(Br)=C1Br)CCCN3C(N4CCNCC4)=N2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– CDK
Isoform
– CDK19;CDK8;CDK9
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
