Download Files:
SEL120-34A
Price range: 93 CAD through 1,277 CAD
Products Details
Product Description
– SEL120-34A is a selective and ATP-competitive inhibitor of CDK8 with IC50s of 4.4 nM, 10.4 nM and 1070 nM for CDK8/CycC, CDK19/CycC and CDK9/cycT. SEL120-34A possesses antitumor activity.
Web ID
– T10744
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C15H18Br2N4
Citations
– 1. Zhang G M, Huang S S, Ye L X, et al. Reciprocal positive regulation between BRD4 and YAP in GNAQ-mutant uveal melanoma cells confers sensitivity to BET inhibitors. Pharmacological Research. 2022: 106464.
References
– Rzymski T, et al. SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Oncotarget. 2017 May 16;8(20):33779-33795.
CAS Number
– 1609522-33-9
Molecular Weight
– C15H18Br2N4
Compound Purity
– 1
SMILES
– CC1=C2C=3N(C(=N2)N4CCNCC4)CCCC3C(Br)=C1Br
Target
– Serine/threonin kinase|||PAI-1|||Serine Protease
Pathway
– Cell Cycle/Checkpoint
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
1000 in stock
