Products Details

Product Description

– sEH/AChE-IN-2 (Compound 12b) is a dual inhibitor of the enzymes soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). sEH/AChE-IN-2 provides cumulative effects against neuroinflammation and memory impairment. sEH/AChE-IN-2 has the potential for the research of Alzheimer’s disease (AD)[1].

Web ID

– HY-145832

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C30H33ClF3N5O3

References

– [1] Codony S, et al. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease. J Med Chem. 2022;65(6):4909-4925.

CAS Number

– 2490589-09-6

Molecular Weight

– 604.06

SMILES

– ClC1=CC2=C(C(NCCCC(N3CCC(CC3)NC(NC4=CC=C(C=C4)OC(F)(F)F)=O)=O)=C5C(CCCC5)=N2)C=C1

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology; Neurological Disease

Solubility

– 10 mM in DMSO

Target

– Cholinesterase (ChE)

Isoform

– AChE

Pathway

– Neuronal Signaling

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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