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SBI-553
Price range: 155 CAD through 1,528 CAD
Products Details
Product Description
– SBI-553 is an effective and brain penetrant NTR1 allosteric modulator (EC50: 0.34 μM).
Web ID
– T16860
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C26H31FN4O2
Citations
– 1. Duan J, Liu H, Zhao F, et al.GPCR activation and GRK2 assembly by a biased intracellular agonist.Nature.2023: 1-6.
2. Chen J, Zhou X, Fu L, et al.Natural Product-Based Screening for Lead Compounds Targeting SARS CoV-2 Mpro[J]. Pharmaceuticals, 2023, 16(5): 767..Pharmaceuticals.2023, 16(5): 767.
3. Duan J, Liu H, Ji Y, et al.Structure of a G protein-coupled receptor with GRK2 and a biased ligand.bioRxiv.2022
References
– Pinkerton AB, et al. Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. J Med Chem. 2019 Aug 20.
CAS Number
– 1849603-72-0
Molecular Weight
– C26H31FN4O2
Compound Purity
– 0.9969
SMILES
– COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(F)CC1
Target
– GSK-3|||Beta Amyloid
Pathway
– GPCR/G Protein
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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