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Sapanisertib
$96 – $540
Products Details
Product Description
– Sapanisertib (INK-128; MLN0128; TAK-228) is an orally available, ATP-dependent mTOR1/2 inhibitor with an IC50 of 1 nM for mTOR kinase.
Web ID
– HY-13328
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C15H15N7O
References
– [1]Liu A, et al. mTOR Mediated Anti-Cancer Drug Discovery. Drug Discovery Today: Therapeutic Strategies. 2009, 6(2), 47-55.|[2]Hsieh AC, et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012 Feb 22;485(7396):55-61.
CAS Number
– 1224844-38-5
Molecular Weight
– 309.33
Compound Purity
– 99.66
SMILES
– NC1=NC=NC2=C1C(C3=CC4=C(C=C3)OC(N)=N4)=NN2C(C)C
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : 55 mg/mL (ultrasonic)
Target
– Autophagy;mTOR
Isoform
– mTOR;mTORC1;mTORC2
Pathway
– Autophagy;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
