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Ruboxistaurin (hydrochloride)
$95 – $1,820
Products Details
Product Description
– Ruboxistaurin (LY333531) hydrochloride is an orally active, selective PKC beta inhibitor (Ki=2 nM). Ruboxistaurin hydrochloride exhibits ATP dependent competitive inhibition of PKC beta I with an IC50 of 4.7 nM. Ruboxistaurin hydrochloride inhibits PKC beta II with an IC50 of 5.9 nM[1][2].
Web ID
– HY-10195B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C28H29ClN4O3
Citations
– ACS Omega. 2020 Oct 12;5(41):26551-26561.|Biosci Rep. 2018 Sep 7;38(5):BSR20171459.|Cell Biosci. 2021 Feb 8;11(1):32.|Diabetes Metab Syndr Obes. 2019 Nov 4;12:2289-2302.|Endocrinology. 2018 May 1;159(5):2253-2263.|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.|Acta Pharm Sin B. 2022.|Trop J Pharm Res. 2022; 21(12): 2508.
References
– [1]Jirousek MR, et al. (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta. J Med Chem. 1996;39(14):2664-2671.|[2]Ruboxistaurin: LY 333531. Drugs R D. 2007;8(3):193-199.|[3]Kunt T, et al. The beta-specific protein kinase C inhibitor ruboxistaurin (LY333531) suppresses glucose-induced adhesion of human monocytes to endothelial cells in vitro. J Diabetes Sci Technol. 2007 Nov;1(6):929-35.|[4]Nonaka A, et al. PKC-beta inhibitor (LY333531) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats. Invest Ophthalmol Vis Sci. 2000 Aug;41(9):2702-6.
CAS Number
– 169939-93-9
Molecular Weight
– 505.01
Compound Purity
– 99.84
SMILES
– O=C1NC(C(C2=CN(C3=CC=CC=C32)CCO[C@H](CN(C)C)CC4)=C1C5=CN4C6=CC=CC=C56)=O.[H]Cl
Clinical Information
– Launched
Research Area
– Metabolic Disease
Solubility
– DMSO : 6.67 mg/mL (ultrasonic)
Target
– PKC
Isoform
– PKCα;PKCβ;PKCγ;PKCδ;PKCε;PKCη
Pathway
– Epigenetics;TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
