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RS102895
$75 – $220
Products Details
Product Description
– RS102895 is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1.
Web ID
– HY-18611A
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C21H21F3N2O2
Citations
– Eur J Pharmacol. 2021, 174165.|Exp Cell Res. 2020 Nov 1;396(1):112289.|Hum Reprod. 2019 Apr 1;34(4):646-658.|J Eur Acad Dermatol Venereol. 2020 Apr;34(4):862-872.|J Interferon Cytokine Res. 2019 Apr;39(4):224-232. |J Interferon Cytokine Res. 2020 May;40(5):245-253.|Life Sci. 2020 Nov 15;261:118360.|Stem Cell Res Ther. 2021 Jul 2;12(1):378.|Cell Death Dis. 2022 Feb 17;13(2):158.|Int Immunopharmacol. 2023 Feb.|J Adv Res. 2020 Jul 22;28:231-243.|J Neuroinflammation. 2023 Nov 17;20(1):270.|Liver Int. 2022 Sep 27.|Mol Med Rep. 2017 Sep;16(3):3387-3394. |Sci Adv. 2023 Aug 2;9(31):eadg6856.|Theranostics. 2020 Apr 27;10(13):5687-5703
References
– [1]Mirzadegan T, et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem. 2000 Aug 18;275(33):25562-71.|[2]Park J, et al. MCP-1/CCR2 system is involved in high glucose-induced fibronectin and type IV collagen expression in cultured mesangial cells. Am J Physiol Renal Physiol. 2008 Sep;295(3):F749-57.|[3]Ren F, et al. Analgesic Effect of Intrathecal Administration of Chemokine Receptor CCR2 Antagonist is Related to Change in Spinal NR2B, nNOS, and SIGIRR Expression in Rat with Bone Cancer Pain. Cell Biochem Biophys. 2015 Jun;72(2):611-6.
CAS Number
– 300815-41-2
Molecular Weight
– 390.40
Compound Purity
– 99.97
SMILES
– O=C1NC2=CC=CC=C2C3(CCN(CCC4=CC=C(C(F)(F)F)C=C4)CC3)O1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Endocrinology
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– CCR
Isoform
– CCR1;CCR2
Pathway
– GPCR/G Protein;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
