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Products Details
Product Description
– RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC50=10 nM). RIPK3 mediates the phosphorylation of Mixed Lineage Kinase (MLKL) and causes necroptosis, while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosis. RIPK3-IN-3 also downregulates CXCL5 secretion and inhibits AsPC-1 cell migration and invasion[1].
Web ID
– HY-149393
Shipping
– Room temperature
Molecular Formula
– C16H11N5S
References
– [1]Kim N, et al. Identification of Pyrido [3, 4-d] pyrimidine derivatives as RIPK3-Mediated necroptosis inhibitors[J]. European Journal of Medicinal Chemistry, 2023, 259: 115635…|[2]Namkyoung Kim, et al. Identification of Pyrido[3,4-d]pyrimidine derivatives as RIPK3-Mediated necroptosis inhibitors. Eur J Med Chem. 2023, 259, 115635.
Molecular Weight
– 305.36
SMILES
– C=CC1=NC=C2N=CN=C(NC3=CC(N=CS4)=C4C=C3)C2=C1
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Mixed Lineage Kinase;RIP kinase
Pathway
– Apoptosis;MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
