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RG7800 (tetrahydrochloride)
$80 – $450
Products Details
Product Description
– RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; RG7800 hydrochloride has the potential to treat spinal muscular atrophy.
Web ID
– HY-101792A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C24H32Cl4N6O
Citations
– Nature. 2021 Aug;596(7871):291-295.|Patent. US20230340498A1.|bioRxiv. 2020 Feb.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Life Sci Alliance. 2019 Mar 25;2(2):e201800268.
References
– [1]Ratni H, et al. Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy. J Med Chem. 2016 Jul 14;59(13):6086-100.
Molecular Weight
– 562.36
Compound Purity
– 99.61
SMILES
– CC1=CC(C2CCN(C)CC2)=CN3C1=NC(C4=NN(C=C(C)N=C5CC)C5=C4)=CC3=O.[H]Cl.[H]Cl.[H]Cl.[H]Cl
Clinical Information
– Phase 1
Research Area
– Neurological Disease
Solubility
– H2O : ≥ 113.5 mg/mL
Target
– DNA/RNA Synthesis
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
