Resatorvid
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Resatorvid

SKU TQ0181-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 72 CAD through 1,357 CAD

Products Details

Product Description

– Resatorvid (TAK-242), a selective Toll-like receptor 4 (TLR4) inhibitor, binds directly to Cys747 to prevent TLR4-TIRAP interaction, thereby blocking downstream signaling. Resatorvid exhibits antitumor, anti-inflammatory, and neuroprotective activities.

Web ID

– TQ0181

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C15H17ClFNO4S

Citations

– 1. Chen J, Zhao L, Ding X, et al. Aβ1–40 Oligomers Trigger Neutrophil Extracellular Trap Formation through TLR4- and NADPH Oxidase-Dependent Pathways in Age-Related Macular Degeneration. Oxidative Medicine and Cellular Longevity. 2022 2. Luo D, Han L, Gao S, et al. LINCS Dataset-Based Repositioning of Dutasteride as an Anti-Neuroinflammation Agent. Brain Sciences. 2021, 11(11): 1411.

References

– Zandi Z, et al. The anticancer effect of the TLR4 inhibition using TAK-242 (resatorvid) either as a single agent or in combination with chemotherapy: A novel therapeutic potential for breast cancer. J Cell Biochem. 2020 Feb;121(2):1623-1634.

CAS Number

– 243984-11-4

Molecular Weight

– C15H17ClFNO4S

Compound Purity

– 0.999

SMILES

– CCOC(=O)C1=CCCC[C@H]1S(=O)(=O)Nc1ccc(F)cc1Cl

Pathway

– Autophagy|||Apoptosis|||Immunology/Inflammation

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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