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R406
Price range: 64 CAD through 1,150 CAD
Products Details
Product Description
– R406 (R-406 besylate) is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.
Web ID
– T6174
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C22H23FN6O5·C6H6O3S
Citations
– 1. Li L, Xu X, Lv K, et al. Asebogenin Suppresses Thrombus Formation via Inhibition of Syk Phosphorylation. British Journal of Pharmacology. 2022
2. Zhu Y, Gu H, Yang L, et al. Involvement of MST1/mTORC1/STAT1 activity in the regulation of B-cell receptor signalling by chemokine receptor 2. Clinical and Translational Medicine. 2022, 12(7): e887.
References
– Braselmann S, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther, 2006, 319(3), 998-1008.
CAS Number
– 841290-81-1
Molecular Weight
– C22H23FN6O5·C6H6O3S
Compound Purity
– 0.9882
SMILES
– OS(=O)(=O)c1ccccc1.COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
Pathway
– Angiogenesis|||Tyrosine Kinase/Adaptors|||Apoptosis
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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