– (R)-Dinotefuran ((R)-MTI-446), a neonicotinoid pesticide, demonstrates insecticidal activities 1.7-2.4 times more effective against typical sucking pests like Aphis gossypii and Apolygus lucorum compared to its racemic mixtures, by targeting nicotinic acetylcholine receptors, and is effective in managing these pests while posing a reduced risk to honeybees [1].