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Product Description
– (R)-AS-1 is a selective positive allosteric modulator of excitatory amino acid transporter 2 (EAAT2), with an EC50 of 11 nM. At doses of 60 and 90 mg/kg, (R)-AS-1 enhances spontaneous locomotor activity in mice. It demonstrates anticonvulsant properties in mouse seizure models induced by maximal electroshock (MES), pentylenetetrazole (PTZ), or electric current stimulation (32 or 44 mA), with ED50 values of 66.3, 36.3, 15.6, and 41.6 mg/kg, respectively. This compound is applicable in neurological disease research.
Web ID
– T203260
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C14H16N2O3
CAS Number
– 2506367-95-7
Molecular Weight
– C14H16N2O3
SMILES
– [C@H](C(NCC1=CC=CC=C1)=O)(C)N2C(=O)CCC2=O
Target
– Others
Pathway
– Others
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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