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PYZD-4409
$108 – $780
Products Details
Product Description
– PYZD-4409 is a specific inhibitor of the ubiquitin-activating enzyme UBA1 with an IC50 of 20 μM (cell-free enzymatic assay). PYZD-4409 induces cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells[1].
Web ID
– HY-13297
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C14H7ClFN3O5
References
– [1]Xu GW, et al. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood. 2010 Mar 18;115(11):2251-9.
CAS Number
– 423148-78-1
Molecular Weight
– 351.67
Compound Purity
– 98.0
SMILES
– FC1=CC=C(N2C(/C(C(N2)=O)=CC3=CC=C([N+]([O-])=O)O3)=O)C=C1Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 35 mg/mL
Target
– E1/E2/E3 Enzyme
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
