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Products Details
Product Description
– PROTAC RAR Degrader-1, an RAR degrader, consists of a cIAP1 ligand binding group, a linker, and an RAR ligand binding group. It achieves maximal RAR degradation at a concentration of 30 μM in HT1080 cells. Degradation inducers that utilize cIAP1 are known as specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
Web ID
– T18635
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C51H72N4O11
References
– Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.
CAS Number
– 1351169-27-1
Molecular Weight
– C51H72N4O11
SMILES
– O(CCCNC(COCCOCCOCCNC([C@@H](NC([C@H]([C@@H](CC1=CC=CC=C1)N)O)=O)CC(C)C)=O)=O)C2=C(C(O)=O)C=CC(/C=C/C(=O)C3=CC(C(C)(C)C)=CC(C(C)(C)C)=C3)=C2
Target
– Others
Pathway
– PROTAC
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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