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Products Details
Product Description
– PROTAC K-Ras degrader-2 (compound 48) is a broad-spectrum KRAS mutant PROTAC degrader that demonstrates an IC50 of ≤200 nM for KRAS G12V/RAF1. Additionally, PROTAC K-Ras degrader-2 achieves a DC50 of ≤200 nM in degrading SW620 KRAS G12D and inhibits the growth of SW620 3D cells with an IC50 of ≤20 nM.
Web ID
– T204910
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C52H60F4N8O5
CAS Number
– 3043670-74-9
Molecular Weight
– C52H60F4N8O5
SMILES
– C(C1(COC=2N=C(C3=C(N2)C(F)=C(N=C3)C=4C5=C(C=C(O)C4)C=CC(F)=C5CC)N6C[C@](C)(O)CCC6)CC1)N7CCC(CN8CCN(CC8)C9=CC(F)=C(C(F)=C9)C%10C(=O)NC(=O)CC%10)(C)CC7
Pathway
– GPCR/G Protein|||MAPK|||PROTAC
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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