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Products Details
Product Description
– PROTAC ERα Degrader-2 is composed of a cIAP1 ligand binding group, a linker, and an estrogen receptor α (ERα) binding group, serving as an ERα degrader. It achieves maximal ERα degradation in human mammary tumor MCF7 cells at a concentration of 30 μM. Degradation inducers that utilize cIAP1 are referred to as specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
Web ID
– T18605
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C42H61N5O8
References
– Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.
CAS Number
– 1351169-29-3
Molecular Weight
– C42H61N5O8
SMILES
– C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])(CC/C2=NOCC(NCCOCCOCCNC([C@@H](NC([C@H]([C@@H](CC5=CC=CC=C5)N)O)=O)CC(C)C)=O)=O)[H]
Target
– Others
Pathway
– PROTAC
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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