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PQCA
$400 – $3,400
Products Details
Product Description
– PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively. PQCA is inactive for other muscarinic receptors. PQCA has potential to reduce the cognitive deficits associated with Alzheimer’s disease[1][2].
Web ID
– HY-118342
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C22H20N4O3
References
– [1]Lange HS, et al. The M1 Muscarinic Positive Allosteric Modulator PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys. J Pharmacol Exp Ther. 2015 Dec;355(3):442-50.|[2]Uslaner JM, et al. The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque. Psychopharmacology (Berl). 2013 Jan;225(1):21-30.
CAS Number
– 1144504-35-7
Molecular Weight
– 388.42
Compound Purity
– 99.77
SMILES
– O=C(O)C1=CC(CN2CCC(C#N)(CC2)C3=NC=CC=C3)=C4C=CC=CN4C1=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 10 mg/mL (ultrasonic;warming;heat to 80°C)|Methanol : 50 mg/mL (ultrasonic;adjust pH to 11 with NaOH)
Target
– mAChR
Isoform
– mAChR1
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
