Poloppin
Add to CompareAdded to Compare

Download Files:

Poloppin

SKU T24652-1 mg Category Brand:

This product is currently out of stock and unavailable.

Request Pricing

Products Details

Product Description

– Poloppin is a protein-protein interactions modulator of the mitotic polo-like kinases that acts by targeting mutant KRAS. It works synergistically with Crizotinib, an inhibitor of the c-MET receptor, against mutant KRAS-expressing cancer cells.

Web ID

– T24652

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H15BrF3NO2

References

– Narvaez AJ, Ber S, Crooks A, Emery A, Hardwick B, Guarino Almeida E, Huggins DJ, Perera D, Roberts-Thomson M, Azzarelli R, Hood FE, Prior IA, Walker DW, Boyce R, Boyle RG, Barker SP, Torrance CJ, McKenzie GJ, Venkitaraman AR. Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS. Cell Chem Biol. 2017 Aug 17;24(8):1017-1028.e7. doi: 10.1016/j.chembiol.2017.07.009. Epub 2017 Aug 10. PubMed PMID: 28807782; PubMed Central PMCID: PMC5563081.

CAS Number

– 683808-78-8

Molecular Weight

– C20H15BrF3NO2

SMILES

– OC(=O)CCC1=CC=C(N1C1=C(C=CC=C1)C(F)(F)F)C1=CC=C(Br)C=C1

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Related Products

Select options
Mephenesin
Mephenesin Price range: 53 CAD through 173 CAD
1 g10 g5 g

1000 in stock

Select options
Aspirin
Aspirin Price range: 50 CAD through 139 CAD
1 g1 mL * 10 mM (in DMSO)5 g

1000 in stock

Select options
Jedi2
Jedi2 Price range: 53 CAD through 1,117 CAD
1 mg1 mL * 10 mM (in DMSO)5 mg

1000 in stock

Select options
7-Methoxy-1-tetralone
7-Methoxy-1-tetralone Price range: 46 CAD through 56 CAD
1 g1 mL * 10 mM (in DMSO)

1000 in stock

Select options
4-Hydroxy-6-methylcoumarin
4-Hydroxy-6-methylcoumarin Price range: 46 CAD through 78 CAD
1 mL * 10 mM (in DMSO)500 mg

1000 in stock

My Cart
Wishlist
Recently Viewed
Categories

Request Data Sheet / Safty Data Sheet

Please enable JavaScript in your browser to complete this form.
=

Price Request

Please enable JavaScript in your browser to complete this form.
=

Compare Products (0 Products)
document.addEventListener('elementor/popup/show', function() { if (typeof turnstile !== 'undefined') { document.querySelectorAll('.cf-turnstile').forEach(function(el) { if (!el.dataset.rendered) { turnstile.render(el); el.dataset.rendered = true; } }); } });